Improving fracture healing using a local delivery of parathyroid hormone
Non-hormonal function of locally delivered PTH for rescue of impaired fracture healing
This study is looking at a new way to help heal broken bones faster by using a special hormone delivered right to the fracture site, and it's designed for people who might have trouble healing due to diabetes, smoking, or being older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10617664 on NIH RePORTER |
What this research studies
This research investigates the use of a locally delivered parathyroid hormone (hPTH1-34) to enhance the healing of fractures, particularly in patients who experience impaired healing due to conditions like diabetes, chronic smoking, or advanced age. The approach focuses on delivering the hormone directly to the fracture site to stimulate the body's own stem cells involved in bone repair. By targeting the specific area of the fracture, the research aims to improve healing outcomes and reduce complications associated with fractures. Patients participating in this research may receive this innovative treatment as part of their care.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals, diabetic patients, and chronic smokers who are experiencing impaired fracture healing.
Not a fit: Patients with healthy fracture healing processes or those not suffering from the specified conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve fracture healing and reduce complications for patients with impaired healing.
How similar studies have performed: While the use of systemic parathyroid hormone has been studied, the local delivery approach is relatively novel and has not been extensively tested in this context.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Lee, Francis Young-in — Yale University
- Study coordinator: Lee, Francis Young-in
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.