Improving fracture healing in patients with breast cancer
Official title: Rescuing impaired fracture healing by molecular targeting
Funded at Yale University · NIH-11036375 · Data updated 2026-11-12
This study is looking at how breast cancer cells can slow down the healing of broken bones, and it aims to find ways to improve healing while also tackling cancer growth, so it's especially for people dealing with both breast cancer and fractures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | March 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $485,368 |
| NIH project number | 5R01AR081656-02 |
| Project ID | NIH-11036375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with breast cancer who are experiencing fractures or have a history of impaired fracture healing.
✕Less likely to help
Patients without breast cancer or those who do not have issues with fracture healing may not benefit from this research.
What this research studies
This research investigates how breast cancer cells affect the healing of fractures, particularly focusing on the mechanisms that lead to impaired healing in the presence of these cancer cells. The study aims to understand the biological signals and inflammatory responses that hinder the healing process, using advanced techniques like RNA sequencing to analyze the behavior of different breast cancer cells in bone environments. By uncovering these mechanisms, the research seeks to develop targeted treatments that can enhance fracture healing while also addressing cancer growth.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve fracture healing in patients with breast cancer, significantly enhancing their recovery and quality of life.
How similar studies have gone: Other research has shown promising results in understanding the interactions between cancer and bone healing, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Lee, Francis Young-in — Yale University
- Study coordinator: Lee, Francis Young-in
Related research
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Intermittent Fasting to Boost Fracture Healing in Obesity and Type 2 Diabetes
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-
Next-Generation MRI to Predict Bone Healing Using Virtual Testing
A new MRI-based method uses advanced imaging and computer models to predict how well broken bones are healing, starting with shinbone (tibial) fractures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.