Improving fracture healing in patients with breast cancer
Rescuing impaired fracture healing by molecular targeting
This study is looking at how breast cancer cells can slow down the healing of broken bones, and it aims to find ways to improve healing while also tackling cancer growth, so it's especially for people dealing with both breast cancer and fractures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11036375 on NIH RePORTER |
What this research studies
This research investigates how breast cancer cells affect the healing of fractures, particularly focusing on the mechanisms that lead to impaired healing in the presence of these cancer cells. The study aims to understand the biological signals and inflammatory responses that hinder the healing process, using advanced techniques like RNA sequencing to analyze the behavior of different breast cancer cells in bone environments. By uncovering these mechanisms, the research seeks to develop targeted treatments that can enhance fracture healing while also addressing cancer growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast cancer who are experiencing fractures or have a history of impaired fracture healing.
Not a fit: Patients without breast cancer or those who do not have issues with fracture healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve fracture healing in patients with breast cancer, significantly enhancing their recovery and quality of life.
How similar studies have performed: Other research has shown promising results in understanding the interactions between cancer and bone healing, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Lee, Francis Young-in — Yale University
- Study coordinator: Lee, Francis Young-in
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.