NIH-funded research R37 grant

Improving follow-up care after removing precancerous polyps to prevent colorectal cancer

Official title: Personalizing Post-Polypectomy Surveillance for Colorectal Cancer Prevention

Funded at Kaiser Foundation Research Institute · NIH-10931664 · Data updated 2026-11-12

This study is looking to improve the follow-up care for people who have had precancerous polyps removed during colon screenings by creating a better way to figure out who is at higher risk for colorectal cancer, so that those who need more monitoring get it, while those at lower risk can avoid extra procedures.

More Colorectal Cancer research and trials

Quick facts

Grant typeR37 grant
Study typeNIH-funded research
Funding institutionKaiser Foundation Research Institute
NIH-funded
Lab location1 site (Oakland, UNITED STATES)
Project startSeptember 19, 2023
Project endAugust 31, 2028
Funding year2024
Award (this year)$658,509
NIH project number5R37CA276306-02
Project IDNIH-10931664 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals who have had precancerous polyps detected and removed during colorectal cancer screening.

Less likely to help

Patients who have not undergone colorectal cancer screening or do not have a history of precancerous polyps may not benefit from this research.

What this research studies

This research focuses on enhancing the follow-up care for individuals who have had precancerous polyps removed during colorectal cancer screening. It aims to develop a more accurate risk assessment method that considers both clinical and genetic factors, rather than relying solely on polyp characteristics. By doing so, the study seeks to identify patients who are at higher risk for developing colorectal cancer and tailor their surveillance schedules accordingly. This personalized approach could reduce unnecessary procedures for low-risk patients while ensuring high-risk individuals receive timely monitoring.

Why it matters

Potential benefit: If successful, this research could lead to more effective colorectal cancer prevention strategies, reducing the incidence of cancer and improving patient outcomes.

How similar studies have gone: Previous research has shown promise in using genetic and clinical factors for risk stratification in colorectal cancer, indicating that this approach could be effective.

Where this research is happening

  • Kaiser Foundation Research Institute
    Oakland, United States
    Active

Researchers

  • Principal investigator: Lee, Jeffrey Kuang Zou — Kaiser Foundation Research Institute
  • Study coordinator: Lee, Jeffrey Kuang Zou

Related research

Other NIH-funded projects on the same topics.

  • Improving colorectal cancer screening and follow-up care.

    This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.

    NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-9627071

  • Colorectal cancer prognosis through a broad, collaborative study

    A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11590756

  • Ceramides and how they affect metabolism and colorectal cancer in adults

    A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11535283

  • Automated point-of-care DNA methylation test for colorectal cancer in LMICs

    A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11531863

  • Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation

    A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.

    NIH research Yale University · New Haven, United States · NIH-11505210

  • Comparative modeling to guide colorectal cancer screening and care

    A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.

    NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11495363

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.