Improving fluorescent sensors to visualize brain signaling in real-time
Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulation
This study is working on improving special tools that can help us see how important brain chemicals like dopamine and serotonin are working, which could help us understand things like addiction, attention, and mood better, ultimately benefiting patients by giving us more insight into how these chemicals affect our behavior.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10894864 on NIH RePORTER |
What this research studies
This research focuses on enhancing genetically-encoded fluorescent indicators that can visualize the activity of key neuromodulators in the brain, such as dopamine and serotonin. By optimizing these sensors, the project aims to improve their effectiveness in measuring brain signaling related to behaviors like addiction, attention, and mood. The approach involves advanced imaging techniques and iterative testing to ensure the sensors are both bright and specific, allowing for better understanding of neuromodulation in living organisms. Patients may benefit from insights gained into how these neuromodulators affect various brain functions and behaviors.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions influenced by neuromodulators, such as addiction, anxiety, or depression.
Not a fit: Patients with neurological conditions unrelated to neuromodulation may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating conditions related to neuromodulation, such as addiction and mood disorders.
How similar studies have performed: Previous research has shown promise in using genetically-encoded indicators for imaging brain activity, suggesting that this approach could yield significant advancements.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hires, Samuel Andrew — University of Southern California
- Study coordinator: Hires, Samuel Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.