Improving fatigue management for women with metastatic breast cancer
Official title: Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-10873532 · Data updated 2026-11-12
This study is testing a new online therapy program called Energize-MBC designed to help women with metastatic breast cancer who feel tired from their treatment, making it easier for them to feel better and enjoy their daily lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $319,163 |
| NIH project number | 1R34CA289918-01 |
| Project ID | NIH-10873532 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with metastatic breast cancer who are currently receiving treatment with CDK4/6 inhibitors.
✕Less likely to help
Patients who do not have metastatic breast cancer or are not undergoing treatment with CDK4/6 inhibitors may not benefit from this research.
What this research studies
This research focuses on adapting a cognitive behavioral therapy program specifically for women with metastatic breast cancer who experience fatigue due to treatment with CDK4/6 inhibitors. The program, called Energize-MBC, aims to enhance the quality of life for these patients by addressing their unique needs. The approach includes refining a web-based platform for delivering therapy via telemedicine, making it accessible and convenient. The study will evaluate how feasible and acceptable this adapted therapy is, as well as its preliminary effectiveness in reducing fatigue and improving daily functioning.
Why it matters
Potential benefit: If successful, this research could significantly reduce fatigue and improve the quality of life for women living with metastatic breast cancer.
How similar studies have gone: Previous research has shown that cognitive behavioral therapy can effectively reduce fatigue in cancer patients, suggesting that this adapted approach may also be beneficial.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Jim, Heather S.l. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Jim, Heather S.l.
Related research
Other NIH-funded projects on the same topics.
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Energize-MBC: a web-based fatigue program for women with metastatic breast cancer
This project will adapt a cognitive behavioral therapy program delivered online to help women with metastatic breast cancer who have tiring side effects from CDK4/6 inhibitor treatment.
-
Understanding FGFR1-amplified breast cancer to overcome endocrine resistance
This project explores why a type of breast cancer with FGFR1 changes stops responding to hormone therapy and looks for new combination treatments that may help patients live longer.
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Oral fulvestrant as the next standard of care for ER+ metastatic breast cancer
A new oral formulation of fulvestrant is being tested to help people with ER-positive metastatic breast cancer have a longer, better-tolerated response to treatment.
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Fit2ThriveMB: A digital activity program to help people with metastatic breast cancer feel better and stay active
A digital, at-home physical activity program designed for people with metastatic breast cancer to improve quality of life and daily functioning.
-
Acupuncture to ease symptoms for people with metastatic breast cancer
A clinical trial will test whether weekly acupuncture for 12 weeks can reduce symptom burden for people with metastatic breast cancer who are on standard therapy.
-
Predicting end-of-life timing to guide better care for metastatic breast cancer
A clinician-facing project tests a breast cancer prognostic tool in everyday oncology care to help guide conversations and timely hospice referrals for patients nearing the end of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.