Improving fat cell communication to enhance metabolism and weight loss
Official title: Enhancing metabolic action of FGF21 through adipocyte Connexin43 gap junction channels
Funded at Baylor College of Medicine · NIH-10917213 · Data updated 2026-11-12
This study is looking at how better communication between fat cells can help them respond to a hormone that helps with weight loss and metabolism, using a special compound to see if it can make this process work better for people with obesity and Type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $437,829 |
| NIH project number | 5R01DK136619-02 |
| Project ID | NIH-10917213 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are obese or have Type 2 diabetes and are seeking improved therapeutic options.
✕Less likely to help
Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
What this research studies
This research investigates how enhancing communication between fat cells can improve their response to a hormone called FGF21, which is important for regulating metabolism and weight. The approach focuses on activating specific channels in fat cells, known as connexin43 gap junctions, to allow better sharing of signals that promote metabolic activity. By using a compound called danegaptide, the researchers aim to boost the effectiveness of FGF21 in promoting weight loss and improving metabolic health, particularly in individuals with obesity and Type 2 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for obesity and Type 2 diabetes, helping patients achieve better weight management and metabolic health.
How similar studies have gone: Previous research has shown promising results with similar approaches, indicating potential for success in this area.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Zhu, Yi — Baylor College of Medicine
- Study coordinator: Zhu, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.