Improving eye treatment for herpes simplex virus infections using adefovir dipivoxil
Official title: Repurposing and reformulation of adefovir dipivoxil for improved topical treatment of herpes simplex virus infection of the eye
Funded at University of Arizona · NIH-10902619 · Data updated 2026-11-12
This study is looking at a new way to treat herpes simplex virus keratitis, which can cause serious eye problems, by using a medication called adefovir dipivoxil in a form that’s easier to use and needs to be applied less often, making it better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $657,537 |
| NIH project number | 1R01EY036247-01 |
| Project ID | NIH-10902619 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with herpes simplex virus keratitis who require topical antiviral treatment.
✕Less likely to help
Patients with other types of eye infections or those who do not have herpes simplex virus keratitis may not benefit from this research.
What this research studies
This research focuses on enhancing the treatment of herpes simplex virus keratitis, a leading cause of blindness due to corneal infections. The study aims to repurpose adefovir dipivoxil, an existing antiviral medication, to create a more effective topical treatment that requires less frequent application than current therapies. By investigating the optimal formulation and dosing schedule, the research seeks to improve patient adherence and therapeutic outcomes. The approach includes testing the drug's effectiveness in a controlled setting to ensure it is both safe and potent against the virus.
Why it matters
Potential benefit: If successful, this research could lead to a more effective and user-friendly treatment for patients suffering from ocular herpes infections, potentially reducing the risk of blindness.
How similar studies have gone: Previous research has shown promise in repurposing existing antiviral medications for improved efficacy, suggesting that this approach could yield beneficial results.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Date, Abhijit a — University of Arizona
- Study coordinator: Date, Abhijit a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.