Improving Early Detection of Ovarian Cancer
MD Anderson Cancer Center EDRN- Clinical Validation Center for Early Detection of Ovarian Cancer with a multiple marker algorithm
This research aims to find better ways to detect ovarian cancer early in women, which could significantly improve their chances of a cure.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11116887 on NIH RePORTER |
What this research studies
We are working to develop and confirm new methods for finding ovarian cancer when it is still in its early stages. Our approach builds on a strategy that uses a blood test called CA125, combined with a special computer program, to identify women who might need further checks. We are also exploring additional markers like HE4 and osteopontin to make these early detection methods even more accurate. The goal is to catch ovarian cancer sooner, when treatments are most effective.
Who could benefit from this research
Good fit: This research is relevant for women who are at risk for ovarian cancer or those interested in early detection screening.
Not a fit: Patients already diagnosed with advanced ovarian cancer may not directly benefit from this early detection research.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis of ovarian cancer, potentially increasing cure rates by 10-30%.
How similar studies have performed: Previous large-scale studies have shown promising results with a two-stage screening strategy using CA125 and a risk algorithm, detecting early-stage cancers with high accuracy.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Bast, Robert C — University of Tx Md Anderson Can Ctr
- Study coordinator: Bast, Robert C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.