Improving early detection of liver cancer in high-risk American Indian and Alaska Native patients
Risk stratification strategies and abbreviated MRI-based surveillance for early detection of HCC in high-risk AI/AN patients
This study is looking to help American Indian and Alaska Native patients who are at higher risk for liver cancer by creating special tools to identify them and using quicker MRI checks to catch any problems early, so they can get the right care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10706318 on NIH RePORTER |
What this research studies
This research focuses on identifying high-risk American Indian and Alaska Native (AI/AN) patients for hepatocellular carcinoma (HCC) through the development of specific risk calculators based on HBV genotype and mutations. The project aims to enhance early detection by utilizing abbreviated MRI surveillance strategies tailored for this population. By investigating the relationship between HBV mutations and HCC development, the research seeks to create personalized monitoring approaches for those at increased risk. Patients will be involved in a pilot study to test these new surveillance methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are American Indian and Alaska Native individuals with a history of hepatitis B virus infection or cirrhosis.
Not a fit: Patients who do not have hepatitis B virus infection or cirrhosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of liver cancer in high-risk patients, improving treatment outcomes and survival rates.
How similar studies have performed: Previous research has shown promise in using genotype-specific approaches for cancer risk assessment, indicating potential success for this novel strategy.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Ioannou, George — University of Washington
- Study coordinator: Ioannou, George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.