Improving drug safety and effectiveness for kidney treatments using advanced tissue models
Translational center for kidney microphysiological systems to improve drug safety and efficacy
This study is working on creating tiny models of human kidneys to help researchers understand how new medicines for kidney diseases work and to spot any possible side effects before they are tested in people, which could lead to safer and more effective treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11016967 on NIH RePORTER |
What this research studies
This research focuses on developing kidney microphysiological systems, which are advanced models that mimic human kidney function, to enhance the safety and efficacy of drugs targeting kidney diseases. By utilizing these innovative tissue chips, researchers aim to better understand how drugs interact with kidney cells and to identify potential side effects before clinical trials. The approach seeks to overcome the limitations of traditional animal models, which often fail to accurately represent human kidney conditions. Patients may benefit from more effective and safer kidney treatments as a result of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from various kidney diseases who are seeking new treatment options.
Not a fit: Patients with acute kidney injury or those who do not have any kidney-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective drug therapies for patients with kidney diseases.
How similar studies have performed: Previous research has shown promise in using microphysiological systems for drug testing, indicating potential success for this novel approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Himmelfarb, Jonathan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Himmelfarb, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.