Improving drug effectiveness and safety in emergency care
Official title: Personalizing EmerGency/Acute therapeuticS Utilizing Systems biology (PEGASUS-2)
Funded at Denver Health and Hospital Authority · NIH-11020943 · Data updated 2026-11-12
The PEGASUS-2 program is working to make emergency treatments safer and more effective by studying how different patients respond to medications, so they can create personalized treatment plans that help everyone feel better faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Denver Health and Hospital Authority NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | February 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $368,010 |
| NIH project number | 5R35GM152157-03 |
| Project ID | NIH-11020943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients presenting with acute conditions such as nausea, pain, or cardiovascular diseases in emergency settings.
✕Less likely to help
Patients with chronic conditions or those not requiring acute care may not receive benefits from this research.
What this research studies
The PEGASUS-2 program aims to enhance the effectiveness and safety of drug treatments for common acute conditions encountered in emergency departments. By utilizing advanced systems biology techniques, the research will analyze various biological data, including pharmacogenomic and metabolomic information, to better understand how different patients respond to medications. This approach will involve collecting and integrating data from a biorepository that focuses on patients with acute illnesses, allowing for personalized treatment strategies. The ultimate goal is to develop models that can predict therapeutic success for acutely ill patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer drug therapies for patients experiencing acute medical conditions.
How similar studies have gone: Previous research has shown promise in using precision medicine approaches in acute care settings, indicating potential for success in this novel application.
Where this research is happening
-
Denver Health and Hospital Authority
Denver, United States Active
Researchers
- Principal investigator: Monte, Andrew Albert — Denver Health and Hospital Authority
- Study coordinator: Monte, Andrew Albert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.