Improving drug development by understanding how drugs interact with biological systems
Systems Approaches for Opening Therapeutic Windows
This study is looking at ways to make old drugs work better by combining them with others to help treat conditions more effectively, so patients might eventually get access to new and improved medications that were once considered failures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10686679 on NIH RePORTER |
What this research studies
This research focuses on enhancing drug development by exploring how drugs affect physiological systems. It aims to convert failed drugs into effective treatments by using a combination of drugs that target the same biological networks, thereby widening their therapeutic windows. New screening methods will be developed to identify these therapeutic windows, and the project will also categorize disease mechanisms into common patterns to better understand how they can be treated. Patients may benefit from more effective medications that were previously deemed unsuccessful.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with conditions that currently lack effective treatment options or for whom existing drugs have failed.
Not a fit: Patients with well-established treatment options that are already effective for their conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective drugs for various diseases, increasing treatment options for patients.
How similar studies have performed: Other research has shown promise in using systems approaches to improve drug development, suggesting that this methodology could yield significant advancements.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Stites, Edward C. — Yale University
- Study coordinator: Stites, Edward C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.