Improving drug delivery to brain tumors using focused ultrasound and vascular normalization
Augmenting focused ultrasound-mediated drug delivery to brain tumors with vascular normalization
['FUNDING_R21'] · UNIVERSITY OF VIRGINIA · NIH-10933855
This study is exploring a new way to help deliver cancer-fighting drugs more effectively to brain tumors by using focused ultrasound and tiny bubbles, which could make treatments work better for patients.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10933855 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to enhance the delivery of therapeutic agents to brain tumors by using focused ultrasound in combination with microbubbles. The study aims to overcome the challenges posed by the blood-tumor barrier, which restricts effective drug penetration. By normalizing the tumor's blood vessels through a specific pharmacological intervention, the researchers hope to improve blood flow and reduce pressure within the tumor, thereby facilitating better drug delivery. Patients may benefit from this innovative method that seeks to make existing treatments more effective.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with brain tumors who are seeking more effective treatment options.
Not a fit: Patients with brain tumors that are not amenable to drug therapy or those who are not eligible for focused ultrasound treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the effectiveness of drug treatments for patients with brain tumors.
How similar studies have performed: Previous research has shown promise in using focused ultrasound for drug delivery, but this specific combination with vascular normalization is a novel approach.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRICE, RICHARD J. — UNIVERSITY OF VIRGINIA
- Study coordinator: PRICE, RICHARD J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.