Improving drug delivery for safer cancer treatment using radiation
Imaging radiation-enhanced drug delivery for safer and more effective chemoradiotherapy
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11127053
This study is looking at how using radiation therapy can help make chemotherapy work better for people with advanced head and neck cancers, aiming to improve treatment results while reducing side effects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11127053 on ClinicalTrials.gov |
What this research studies
This research investigates how radiation therapy can enhance the delivery of chemotherapy specifically to tumors, potentially improving treatment outcomes for patients with locally advanced head and neck squamous cell carcinoma and anaplastic thyroid cancer. By examining the effects of radiation on the tumor microenvironment, the study aims to identify ways to increase the effectiveness of drug delivery while minimizing side effects. The approach includes advanced imaging techniques and immune response analysis in both mouse models and patient-derived samples. Ultimately, the goal is to develop a safer and more effective combination of radiation and chemotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with locally advanced head and neck squamous cell carcinoma or anaplastic thyroid cancer who are undergoing chemoradiotherapy.
Not a fit: Patients with early-stage cancers or those not receiving chemoradiotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments with fewer side effects for patients.
How similar studies have performed: Preliminary studies have shown promise in enhancing drug delivery through radiation, indicating that this approach may be effective.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, MILES A — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: MILLER, MILES A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anaplastic thyroid cancer