Improving drug delivery for better treatment outcomes
Prodrug engineering for enhanced biodistribution and pharmacokinetics
This study is working on new ways to help small drugs used for treating diseases like cancer and heart problems reach the right places in the body more effectively, so patients can feel better with fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami Coral Gables NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10940885 on NIH RePORTER |
What this research studies
This research focuses on enhancing the delivery and effectiveness of small molecular drugs used to treat various diseases, including cancer and cardiovascular conditions. It aims to develop innovative drug delivery systems that can improve how these drugs are distributed in the body and how they interact with target sites. The approach includes creating targeted prodrugs that bind to albumin in the bloodstream, allowing for more efficient transport to diseased areas, and responsive polymer prodrugs that release medication in a controlled manner. By addressing the limitations of current drug delivery methods, this research seeks to reduce side effects and improve therapeutic outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers or cardiovascular diseases who may benefit from improved drug delivery systems.
Not a fit: Patients with conditions that do not involve the use of small molecular drugs or those who are not undergoing treatment for the targeted diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments with fewer side effects for patients suffering from serious diseases.
How similar studies have performed: Previous research has shown promise in improving drug delivery systems, indicating that this approach has the potential for success.
Where this research is happening
Coral Gables, United States
- University of Miami Coral Gables — Coral Gables, United States (Active)
Researchers
- Principal investigator: Zhang, Fuwu — University of Miami Coral Gables
- Study coordinator: Zhang, Fuwu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.