Improving DNA analysis using advanced optical mapping techniques
Official title: Super-Resolution Optical Mapping for DNA Analysis Using Triplex-Forming Oligonucleotides as Stochastic Molecular Probes
Funded at Ohio University Athens · NIH-10653619 · Data updated 2026-11-12
This study is working on new ways to look at DNA more clearly without needing to take samples, which could help patients get more accurate information about their genes and improve treatments for genetic conditions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 1, 2018 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $448,094 |
| NIH project number | 2R15HG009972-02 |
| Project ID | NIH-10653619 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or those undergoing genetic testing who may benefit from enhanced DNA analysis.
✕Less likely to help
Patients who do not have genetic conditions or are not undergoing genetic testing may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing the accuracy of DNA analysis through the development of non-invasive molecular probes for super-resolution optical mapping. By using advanced imaging techniques, the project aims to overcome limitations of traditional methods that can only resolve DNA structures at a certain scale. Patients may benefit from improved genome sequencing accuracy, which can lead to better understanding and treatment of genetic conditions. The research involves collaboration and innovative approaches to tackle existing technical challenges in DNA mapping.
Why it matters
Potential benefit: If successful, this research could lead to more accurate DNA sequencing, improving diagnosis and treatment options for genetic disorders.
How similar studies have gone: While the approach of using non-invasive probes for optical mapping is innovative, similar techniques in DNA analysis have shown promise in other studies, indicating potential for success.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Chen, Jixin — Ohio University Athens
- Study coordinator: Chen, Jixin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.