Improving dialysis membranes to better remove harmful toxins from blood
Official title: Enhanced renal dialysis membrane performance using lipocalin modified substrates
Funded at Hibar Microsciences, LLC · NIH-10691958 · Data updated 2026-11-12
This study is looking at ways to make dialysis treatments better for people with kidney failure by using special proteins to help remove harmful toxins from their blood more effectively.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hibar Microsciences, LLC NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $299,999 |
| NIH project number | 1R43DK134225-01A1 |
| Project ID | NIH-10691958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are undergoing hemodialysis due to end-stage renal disease.
✕Less likely to help
Patients who do not require dialysis or have functioning kidneys will not benefit from this research.
What this research studies
This research focuses on enhancing the performance of dialysis membranes used in treating patients with end-stage renal disease (ESRD). The approach involves modifying membranes with Lipocalin proteins to improve the clearance of harmful protein-bound uremic toxins from the blood, which are often not effectively removed by current dialysis methods. By utilizing advanced techniques, the study aims to demonstrate increased extraction rates of these toxins, potentially leading to better health outcomes for patients undergoing dialysis.
Why it matters
Potential benefit: If successful, this research could lead to more effective dialysis treatments, improving the health and quality of life for patients with chronic kidney disease.
How similar studies have gone: Previous research has shown promise in enhancing dialysis technologies, but this specific approach using Lipocalin-modified membranes is novel and has not been extensively tested.
Where this research is happening
-
Hibar Microsciences, LLC
Atlanta, United States Active
Researchers
- Principal investigator: Tumlin, James a — Hibar Microsciences, LLC
- Study coordinator: Tumlin, James a
Related research
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-
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A real-world trial tests adding community health workers to an interdisciplinary CKD clinic to help patients access home dialysis options.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.