Improving diagnosis of thyroid nodules to reduce unnecessary surgeries
Development of a multi-analyte diagnostic assay to improve the risk stratification of indeterminate thyroid nodules
This study is working on a new test to help doctors figure out if thyroid nodules are cancerous or not, so patients can avoid unnecessary surgeries.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Alaunus Biosciences, INC. NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project ID | NIH-10684875 on NIH RePORTER |
What this research studies
This research focuses on developing a new diagnostic test to better assess thyroid nodules that are often found incidentally during imaging. Currently, many patients undergo unnecessary surgeries because existing tests cannot definitively determine whether these nodules are cancerous. The researchers are using advanced techniques to analyze enzyme activity in tissue samples, which may help distinguish between benign and malignant nodules more accurately. By identifying specific biomarkers associated with cancer, the goal is to reduce the number of patients who need invasive procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with indeterminate thyroid nodules and are facing the possibility of surgery.
Not a fit: Patients with clearly diagnosed malignant thyroid nodules or those without thyroid nodules may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce unnecessary thyroid surgeries and improve the accuracy of cancer diagnoses for patients with thyroid nodules.
How similar studies have performed: Previous research has shown promise in using proteomics for cancer diagnostics, indicating that this approach may lead to significant advancements in the field.
Where this research is happening
Novato, United States
- Alaunus Biosciences, INC. — Novato, United States (Active)
Researchers
- Principal investigator: Knudsen, Giselle M — Alaunus Biosciences, INC.
- Study coordinator: Knudsen, Giselle M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.