Improving diagnosis of peripheral artery disease in patients with chronic kidney disease
Official title: Establishing A New Diagnostic Paradigm for Peripheral Artery Disease among Patients with Chronic Kidney Disease
Funded at Tulane University of Louisiana · NIH-10677577 · Data updated 2026-11-12
This study is looking to improve how we diagnose peripheral artery disease (PAD) in people who also have chronic kidney disease (CKD), by testing new ways to measure blood flow that might work better for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $348,116 |
| NIH project number | 5R01HL157903-03 |
| Project ID | NIH-10677577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with chronic kidney disease who may also be at risk for peripheral artery disease.
✕Less likely to help
Patients without chronic kidney disease or those who do not have risk factors for peripheral artery disease may not benefit from this research.
What this research studies
This research aims to develop a new diagnostic approach for peripheral artery disease (PAD) specifically in patients who have chronic kidney disease (CKD). It investigates how traditional diagnostic methods may not accurately identify PAD in CKD patients due to unique vascular conditions such as arterial stiffness. The study will evaluate the effectiveness of new cut-off points for diagnostic tests like the ankle-brachial index (ABI) and toe-brachial index (TBI) to better detect PAD in this population. By analyzing various cardiovascular risk factors, the research seeks to enhance the accuracy of PAD diagnosis among CKD patients.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses of peripheral artery disease in patients with chronic kidney disease, potentially improving their treatment outcomes.
How similar studies have gone: Previous studies have indicated that traditional diagnostic criteria may not be effective for CKD patients, suggesting that this research could fill a critical gap in understanding PAD in this population.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Chen, Jing — Tulane University of Louisiana
- Study coordinator: Chen, Jing
Related research
Other NIH-funded projects on the same topics.
-
Better Ways to Find Peripheral Artery Disease in People with Kidney Disease
This research aims to find more accurate ways to diagnose peripheral artery disease, a condition affecting blood flow to the limbs, in people who also have chronic kidney disease.
-
Using big data to find better treatments for peripheral artery disease in patients with chronic kidney disease
This study is looking at how we can use large amounts of health data to find better treatments for people with peripheral artery disease (PAD) who also have chronic kidney disease (CKD), aiming to improve their care and reduce risks like amputation.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.