Improving diagnosis for patients with undiagnosed diseases
Official title: Clinical Research Support Core
Funded at Harvard Medical School · NIH-11056823 · Data updated 2026-11-12
This study is working to help people with rare and undiagnosed diseases get the right diagnosis faster by using advanced technology and connecting them with experts who can help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 19, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,838,239 |
| NIH project number | 5U2CNS132415-03 |
| Project ID | NIH-11056823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with undiagnosed or rare diseases seeking accurate diagnosis and treatment options.
✕Less likely to help
Patients with well-defined and diagnosed conditions may not benefit from this research.
What this research studies
This research aims to enhance the diagnostic process for patients with undiagnosed and rare diseases by scaling up the individualized translational research methods developed in the Undiagnosed Diseases Network (UDN) and the Undiagnosed Diseases Program (UDP). It will utilize computational models to predict diagnosis likelihood and integrate with national and international matchmaking networks to broaden access to expert consultations. The project will also establish Case Review Committee meetings to streamline evaluations and provide funding to support data sharing and coordination among diagnostic centers.
Why it matters
Potential benefit: If successful, this research could significantly improve diagnostic accuracy and access for patients with undiagnosed diseases.
How similar studies have gone: Previous research has shown success in improving diagnostic processes for rare diseases through collaborative networks and computational modeling.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Cole, Francis Sessions — Harvard Medical School
- Study coordinator: Cole, Francis Sessions
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.