Improving diagnosis for patients with rare and undiagnosed conditions

Diagnosing the Unknown for Care and Advancing Science (DUCAS)

NIH-funded research Harvard Medical School · NIH-11056815

This study is working to make it easier for people with rare or unusual health issues to get the right diagnosis by bringing together experts and sharing important information, so patients can have a smoother journey to better health.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionHarvard Medical School NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-11056815 on NIH RePORTER

What this research studies

This research aims to enhance the diagnostic process for patients suffering from rare conditions or uncommon presentations of common diseases. By building on the success of the Undiagnosed Diseases Network, the project will create a robust infrastructure that integrates data sharing, clinical care, and advanced diagnostics. Patients will benefit from a coordinated approach that brings together experts in various fields to streamline the diagnostic journey and improve patient outcomes. The initiative will also focus on generating new insights into the underlying mechanisms of these diseases.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals with rare diseases or those who have not yet received a diagnosis for their health conditions.

Not a fit: Patients with well-defined and common conditions that are easily diagnosed may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly reduce the time it takes for patients to receive accurate diagnoses, leading to timely and appropriate treatments.

How similar studies have performed: Previous initiatives like the Undiagnosed Diseases Network have shown success in diagnosing complex cases, indicating that this approach has a solid foundation.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.