Improving diagnosis and treatment of uveitis using advanced technology
Official title: Multi-omics Strategies to Improve Clinical Outcomes in Uveitis
Funded at University of California, San Francisco · NIH-10856815 · Data updated 2026-11-12
This study is looking at ways to better diagnose and understand uveitis, an eye condition that can cause serious problems, by using advanced technology to find out what might be causing it and how your body is reacting, so we can help doctors take better care of patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $513,015 |
| NIH project number | 1R01EY036058-01 |
| Project ID | NIH-10856815 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with uveitis, particularly those with infectious cases.
✕Less likely to help
Patients with non-infectious forms of uveitis or those who do not have uveitis may not benefit from this research.
What this research studies
This research focuses on uveitis, an inflammatory eye disease that can lead to blindness if not treated promptly. It aims to enhance diagnostic methods by utilizing high-throughput sequencing to identify infectious causes of uveitis and understand the host's response. The project will involve global surveillance of pathogens and the analysis of gene expression profiles to predict clinical outcomes. By collaborating with various stakeholders, the research seeks to improve classification, diagnosis, and biomarker identification for better patient management.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and improved treatment strategies for patients with uveitis, potentially reducing the risk of blindness.
How similar studies have gone: Previous research utilizing high-throughput sequencing for infectious disease diagnosis has shown promising results, indicating potential success for this approach in uveitis.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Shantha, Jessica — University of California, San Francisco
- Study coordinator: Shantha, Jessica
Related research
Other NIH-funded projects on the same topics.
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Adalimumab Dose Adjustment for Pediatric Uveitis in JIA
A pediatric study will test whether lowering how often kids with juvenile idiopathic arthritis–related uveitis take adalimumab can keep inflammation controlled while reducing side effects and cost.
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Changing adalimumab dosing for children with juvenile arthritis–related eye inflammation
This project tries to see if giving lower or less frequent doses of adalimumab can keep eye inflammation under control in children with juvenile idiopathic arthritis.
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Systemic and topical antiviral treatment for CMV anterior uveitis (STACCATO)
A new NIH-supported effort will test how well oral and eye-applied antiviral medicines control CMV-related anterior uveitis in affected patients.
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Systemic and topical antiviral treatment for CMV anterior uveitis in patients
A patient-friendly look at using antiviral medicines to treat CMV-related eye inflammation and protect vision.
-
Systemic and topical antiviral treatment for CMV anterior uveitis
This project tests how oral and eye-drop antiviral medicines can help prevent vision loss from CMV-related eye inflammation in people with anterior uveitis.
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Systemic and topical antiviral control of CMV anterior uveitis: TreatmentOutcomes
A patient-focused look at how CMV eye inflammation in adults could be treated with pills, eye drops, or other strategies to prevent vision loss.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.