Improving Diagnosis and Treatment for Endometriosis
Collaborative Center to Develop Improved Diagnostic and Therapeutic Approaches to Endometriosis
This collaborative effort aims to better understand endometriosis to help women who experience its pain, infertility, and other challenges.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11175376 on NIH RePORTER |
What this research studies
Endometriosis is a condition where tissue similar to the lining of the uterus grows outside of it, causing severe pain and difficulty getting pregnant. Currently, diagnosing endometriosis often requires surgery, which can delay treatment and make it hard to track the disease over time. Our team believes that a key reason for endometriosis symptoms is that the body's cells become resistant to progesterone, a natural hormone. We are exploring how a specific protein, Sirtuin 1 (SIRT1), might contribute to this progesterone resistance and worsen the condition.
Who could benefit from this research
Good fit: This research is designed to help women who suffer from endometriosis and its associated symptoms like severe pain and infertility.
Not a fit: Patients without endometriosis or those whose symptoms are not related to progesterone resistance may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose endometriosis earlier and more easily, and develop more effective treatments for pain and infertility.
How similar studies have performed: Previous findings by this research group have already shown important connections between Sirtuin 1 and progesterone resistance in endometriosis, building on existing knowledge.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Young, Steven L — Duke University
- Study coordinator: Young, Steven L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.