Improving Detection of Nontuberculous Mycobacteria Outbreaks
Combined Use of Statistical Process Control and Whole Genome Sequencing to Detect and Investigate Nontuberculous Mycobacterial Clusters and Outbreaks
This project aims to find better ways to quickly spot and understand outbreaks of certain bacterial infections, called nontuberculous mycobacteria (NTM), in hospitals, especially for patients with weakened immune systems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11135504 on NIH RePORTER |
What this research studies
Nontuberculous mycobacteria (NTM) are serious infections that can affect many patients, particularly those with weakened immune systems, often appearing in healthcare settings. Currently, it's hard to consistently detect when these infections are spreading, which can delay efforts to stop them. This work combines advanced statistical methods with detailed genetic analysis of the bacteria to create a powerful system for early detection. Our goal is to quickly identify and understand NTM clusters and outbreaks within hospitals, helping to protect vulnerable patients.
Who could benefit from this research
Good fit: Patients who are at risk of or have been affected by nontuberculous mycobacterial infections in healthcare settings are the focus of this research.
Not a fit: Patients not affected by or at risk for nontuberculous mycobacterial infections would not directly benefit from this specific infection control improvement.
Why it matters
Potential benefit: If successful, this approach could lead to earlier detection and better control of NTM outbreaks in hospitals, potentially saving lives and reducing illness for many patients.
How similar studies have performed: While statistical process control and whole genome sequencing are established techniques, their combined use for systematic NTM outbreak detection in this manner represents an innovative approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Baker, Arthur W — Duke University
- Study coordinator: Baker, Arthur W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.