Improving detection of leukemia treatment response and relapse
Measuring treatment response and residual disease in leukemia with personalized, sensitive, and quantitative genomic methods
This study is looking at a new way to check how well leukemia treatments are working and to spot any early signs of the disease coming back, using a special blood test that can find tiny changes in your leukemia over time, helping to improve your care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11073083 on NIH RePORTER |
What this research studies
This research focuses on enhancing the methods used to measure how well leukemia treatments are working and to identify early signs of relapse. It employs a technique called Multiplex Accurate Sensitive Quantitation (MASQ), which can detect specific mutations in leukemia patients' blood samples with high sensitivity. By analyzing these mutations over time, the research aims to provide insights into treatment responses and the potential for relapse, ultimately improving patient outcomes. The study involves tracking patient-specific leukemia-associated variants throughout the course of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia (AML) who are undergoing treatment.
Not a fit: Patients with other types of leukemia or those who are not currently receiving treatment for AML may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate monitoring of treatment responses and earlier detection of relapses in leukemia patients.
How similar studies have performed: Other research has shown promising results using similar genomic approaches to monitor treatment responses in cancer, indicating potential for success in this area.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Moffitt, Andrea — Emory University
- Study coordinator: Moffitt, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.