Improving detection of gene regulation in cancer cells
A multi-level bias correction model for bulk and single-cell CUT&Tag data
['FUNDING_R21'] · UNIVERSITY OF VIRGINIA · NIH-10645980
This study is looking to improve how we detect important changes in genes that can affect cancer, using a special technique to get more accurate results, so that researchers can better understand how genes work in both groups of cells and individual cells.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10645980 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the accuracy of detecting histone modifications and transcription factor binding in cells, which are crucial for understanding how genes are regulated. By utilizing a method called CUT&Tag, the researchers aim to analyze gene expression at both bulk and single-cell levels. The study addresses biases in current data analysis methods that can lead to misleading results, particularly in cancer research. The goal is to develop a multi-level bias correction model that will improve the reliability of these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with various types of cancer where gene regulation plays a significant role in disease progression.
Not a fit: Patients with conditions unrelated to gene regulation or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment strategies for cancers by accurately identifying gene regulation mechanisms.
How similar studies have performed: Previous research using similar epigenomic profiling methods has shown promise in advancing our understanding of gene regulation in cancer.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZANG, CHONGZHI — UNIVERSITY OF VIRGINIA
- Study coordinator: ZANG, CHONGZHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.