Improving detection of biomolecules using electrochemical methods.
Official title: Developing a redox-mediated single NP detection for bioconjugate analysis.
Funded at University of Nevada Reno · NIH-10952012 · Data updated 2026-11-12
This study is exploring a new way to quickly and accurately detect important proteins in the body, like antibodies and antigens, which could help improve tests for various health conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $206,028 |
| NIH project number | 1R21GM155760-01 |
| Project ID | NIH-10952012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring precise biomarker detection for conditions that involve antibody-antigen interactions.
✕Less likely to help
Patients with conditions that do not involve antibody or antigen detection may not benefit from this research.
What this research studies
This research focuses on enhancing the detection of biomolecules, specifically antibodies and antigens, through a novel electrochemical approach. By utilizing single-entity electrochemistry, the study aims to achieve rapid and precise analysis of individual bioconjugates, which are molecules formed by the binding of an antibody to an antigen. The methodology involves tagging antibodies with gold nanoparticles and measuring the electrochemical reactions at ultramicroelectrodes to detect these interactions. This could lead to more efficient diagnostic tools in biomedical research.
Why it matters
Potential benefit: If successful, this research could provide patients with faster and more accurate diagnostic tests for various diseases.
How similar studies have gone: Other research has shown promise in using electrochemical methods for biomolecule detection, indicating potential success for this approach.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Alpuche-Aviles, Mario Alberto — University of Nevada Reno
- Study coordinator: Alpuche-Aviles, Mario Alberto
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.