Improving detection and removal of head and neck cancer using advanced imaging techniques
Targeted Dual Modality Imaging for Detection and Removal of Head and Neck Cancer
This study is testing a new way to help doctors find tiny tumors and affected lymph nodes during surgery for head and neck cancer by using special colored antibodies, which could lead to better treatment results for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10897192 on NIH RePORTER |
What this research studies
This research focuses on enhancing the detection of head and neck squamous cell carcinoma (HNSCC) by using a dual imaging approach that combines fluorescent and nuclear labeled antibodies. The study aims to identify very small tumor deposits and affected lymph nodes during surgery, which traditional methods have struggled to detect. By administering a specific antibody, panitumumab, that targets the epidermal growth factor receptor (EGFR), the researchers hope to improve the accuracy of tumor identification and removal. This innovative technique could lead to better surgical outcomes for patients with HNSCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with head and neck squamous cell carcinoma who are scheduled for surgical intervention.
Not a fit: Patients with advanced metastatic cancer or those not undergoing surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective surgical procedures and improved survival rates for patients with head and neck cancer.
How similar studies have performed: Previous studies have shown promise in using targeted antibodies for cancer detection, indicating that this approach could be effective.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Rosenthal, Eben L. — Vanderbilt University Medical Center
- Study coordinator: Rosenthal, Eben L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.