Improving delivery of osteoarthritis treatments using collagen-based methods
Official title: Collagen-mediated approaches to improve the local delivery and hypothermic release of osteoarthritis therapeutics
Funded at University of Delaware · NIH-10916178 · Data updated 2026-11-12
This study is exploring a new way to deliver treatments for post-traumatic osteoarthritis in the knee by using tiny collagen-based carriers that release medicine right where it's needed, helping to prevent joint pain and stiffness after an injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $610,253 |
| NIH project number | 5R01AR080707-02 |
| Project ID | NIH-10916178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently suffered knee injuries, such as ACL tears or ruptures.
✕Less likely to help
Patients with chronic osteoarthritis unrelated to recent joint injuries may not benefit from this research.
What this research studies
This research focuses on developing a new way to deliver treatments for post-traumatic osteoarthritis (PTOA) that can occur after knee injuries. It aims to create a system that uses collagen-based nanovesicles to release medications directly into the injured joint, helping to prevent the onset of PTOA. By utilizing temperature-sensitive materials, the treatment can provide a sustained release of drugs at body temperature and a quicker release when cooled slightly. This innovative approach seeks to enhance the effectiveness of existing therapies and reduce the need for frequent high-dose drug administration.
Why it matters
Potential benefit: If successful, this research could significantly improve the management and prevention of post-traumatic osteoarthritis in patients with knee injuries.
How similar studies have gone: While this approach is innovative, similar strategies in drug delivery have shown promise in other contexts, suggesting potential for success.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Kiick, Kristi L — University of Delaware
- Study coordinator: Kiick, Kristi L
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.