Improving delivery of DNA nanoparticles for gene therapies
Cytosolic Access and Instability of DNA nanoparticles
This study is looking at how to make tiny DNA particles better at delivering gene therapies, like CRISPR, inside cells, so they can work more effectively in treating conditions that involve gene changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10906861 on NIH RePORTER |
What this research studies
This research focuses on enhancing the delivery of DNA nanoparticles, which are promising carriers for therapies like CRISPR-Cas9 and gene silencing. The project aims to understand how these nanoparticles can effectively escape cellular compartments and remain stable in the cytosol, which is crucial for their therapeutic effectiveness. By integrating calcium into the assembly of these nanoparticles, the researchers hope to improve their ability to reach target areas within cells. This work could lead to significant advancements in the development of more effective gene therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with conditions that could benefit from gene therapies, such as certain types of cancer.
Not a fit: Patients who do not have conditions treatable by gene therapies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for various diseases, including cancer.
How similar studies have performed: Other research has shown promise in using DNA nanoparticles for drug delivery, but the specific approach of enhancing stability and delivery mechanisms is still being explored.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Mathur, Divita — Case Western Reserve University
- Study coordinator: Mathur, Divita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.