Improving delivery of antibodies to prevent HIV transmission
Optimizing AAV delivery of bNAbs for HIV prevention
This study is testing a new way to help protect people from HIV by using a special virus to turn muscle cells into factories that make powerful antibodies, so just one treatment could offer long-lasting protection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10974026 on NIH RePORTER |
What this research studies
This research focuses on using adeno-associated virus (AAV) vectors to enhance the delivery of broadly neutralizing antibodies (bNAbs) for HIV prevention. By transforming muscle cells into factories that produce these antibodies, the goal is to provide a long-lasting protective effect against HIV transmission with a single treatment. The study aims to address challenges posed by the immune system that can limit the effectiveness of AAV vectors, ensuring that more individuals can benefit from this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk of HIV exposure who may benefit from enhanced prevention strategies.
Not a fit: Patients who are already HIV positive or those with pre-existing immunity to AAV vectors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective and cost-efficient method for preventing HIV transmission.
How similar studies have performed: Previous studies have shown promise in using AAV vectors for antibody delivery, but this specific approach is still being explored and is not yet widely tested.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Gardner, Matthew Ryan — Emory University
- Study coordinator: Gardner, Matthew Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.