Improving delivery methods for HIV broadly neutralizing antibodies
Official title: Vector-Based Delivery of HIV Broadly Neutralizing Antibodies
Funded at Cure Systems LLC · NIH-11171844 · Data updated 2026-11-12
This study is working on new ways to deliver powerful antibodies that can help fight HIV-1, making them stronger and longer-lasting, so that people at risk of HIV can have better protection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cure Systems LLC NIH-funded |
| Lab location | 1 site (Newton Center, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $300,000 |
| NIH project number | 75N93024C00048-0-9999-1 |
| Project ID | NIH-11171844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk of HIV infection who may benefit from enhanced preventive measures.
✕Less likely to help
Patients who are already living with HIV and are seeking treatment rather than prevention may not benefit from this research.
What this research studies
This research focuses on developing advanced methods for delivering broadly neutralizing antibodies (bNAbs) that can effectively combat HIV-1. By engineering next-generation bNAb candidates, the project aims to enhance their potency, increase their presence in body tissues, and extend their effectiveness over time. The research also addresses challenges related to the complex pharmacokinetics of these antibodies and aims to create optimized delivery systems that can improve patient outcomes in HIV prevention.
Why it matters
Potential benefit: If successful, this research could provide patients with more effective and longer-lasting protection against HIV infection.
How similar studies have gone: Previous research, such as the Antibody Mediated Prevention (AMP) trials, has shown promise in using broadly neutralizing antibodies for HIV prevention, indicating a potential for success in this novel approach.
Where this research is happening
-
Cure Systems LLC
Newton Center, United States Active
Researchers
- Principal investigator: Miller, Jacqueline — Cure Systems LLC
- Study coordinator: Miller, Jacqueline
Related research
Other NIH-funded projects on the same topics.
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This study is looking for ways to create new treatments for malaria using special antibodies that can help fight the disease, and if you're interested, you might have a chance to join trials to see how safe and effective these treatments are.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.