Improving deep tissue imaging using advanced microscopy techniques
Official title: Computational two-photon microscopy for deep tissue imaging
Funded at University of California at Davis · NIH-10941812 · Data updated 2026-11-12
This study is working on improving a special type of imaging that helps doctors see cells deep inside tissues, which is really important for understanding diseases like Alzheimer's, so they can get clearer pictures and learn more about how these cells work together.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $374,399 |
| NIH project number | 1R35GM155193-01 |
| Project ID | NIH-10941812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who may benefit from advanced imaging techniques.
✕Less likely to help
Patients with conditions unrelated to Alzheimer's or those who do not require deep tissue imaging may not receive any benefit from this research.
What this research studies
This research focuses on enhancing the capabilities of two-photon microscopy to visualize cells deep within biological tissues, which is crucial for understanding various diseases, including Alzheimer's. The team aims to overcome current limitations in imaging depth caused by tissue scattering by developing innovative hardware and software solutions. By utilizing advanced light modulation and computational algorithms, they hope to achieve clearer images from deeper tissue layers, providing valuable insights into cellular functions and interactions. This approach could significantly improve the ability to study complex biological processes in real-time.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for conditions like Alzheimer's disease by allowing for more detailed observation of cellular changes in deep tissues.
How similar studies have gone: Previous research has shown promise in enhancing imaging techniques for biological tissues, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Xue, Yi — University of California at Davis
- Study coordinator: Xue, Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.