Improving deep brain stimulation models for better treatment outcomes
Optimizing Patient-Specific Deep Brain Stimulation Models Using Electrophysiology
This study is working on creating personalized computer models to see how deep brain stimulation helps people with Parkinson's disease, aiming to improve treatment outcomes by better understanding how the stimulation affects the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11009509 on NIH RePORTER |
What this research studies
This research focuses on creating patient-specific computational models for deep brain stimulation (DBS) to better understand how electrical stimulation affects brain structures in conditions like Parkinson's disease. By using advanced 3D imaging and biophysical modeling, the project aims to visualize neuronal activation patterns around the DBS electrodes and in connected brain regions. The goal is to enhance the accuracy of these models to ensure they reflect actual neuronal activations, which could lead to improved clinical outcomes for patients receiving DBS. The research will involve experimental paradigms to assess the effectiveness of these models in real-world scenarios.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or other neuropsychiatric disorders who are considering or currently undergoing deep brain stimulation therapy.
Not a fit: Patients who do not have neuropsychiatric disorders or those who are not candidates for deep brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective deep brain stimulation treatments, improving quality of life for patients with neuropsychiatric disorders.
How similar studies have performed: Previous research has shown promise in using patient-specific models for DBS, but this approach aims to refine and validate these models further, making it a novel and critical advancement.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Miocinovic, Svjetlana — Emory University
- Study coordinator: Miocinovic, Svjetlana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.