Improving decision support systems for preventing blood clots in hospitalized patients
Official title: Evaluation of the SCALED (SCaling AcceptabLE cDs) Approach for the Implementation of Interoperable CDS for Venous Thromboembolism Prevention
Funded at University of Minnesota · NIH-10893358 · Data updated 2026-11-12
This study is working on improving tools that help doctors make better decisions about preventing blood clots, so patients can get the best care based on the latest research.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $974,802 |
| NIH project number | 5R18HS028583-03 |
| Project ID | NIH-10893358 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized patients at risk for venous thromboembolism, particularly those with conditions that may lead to blood clot formation.
✕Less likely to help
Patients who are not hospitalized or those who do not have risk factors for venous thromboembolism may not benefit from this research.
What this research studies
This research focuses on enhancing clinical decision support (CDS) systems to ensure that patients receive evidence-based care, particularly in preventing venous thromboembolism (blood clots). The approach, known as SCALED, aims to create interoperable CDS tools that can be easily integrated into various healthcare systems. By collaborating with technology developers, the project seeks to streamline the implementation of clinical guidelines and improve patient outcomes through better access to updated medical knowledge. The goal is to reduce the gap between research evidence and actual patient care.
Why it matters
Potential benefit: If successful, this research could lead to more patients receiving appropriate and effective care for preventing blood clots, reducing complications and improving overall health outcomes.
How similar studies have gone: Previous research has shown success in implementing interoperable CDS systems, indicating that this approach has the potential for meaningful advancements in patient care.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Tignanelli, Christopher J — University of Minnesota
- Study coordinator: Tignanelli, Christopher J
Related research
Other NIH-funded projects on the same topics.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large study will test whether taking rosuvastatin every day for a year can lower the chance of dangerous blood clots in people with cancer, without raising the risk of bleeding.
-
Optimal use of blood thinners for venous clots in people with cirrhosis
This grant hopes to figure out the safest and most effective way to use oral anticoagulants for adults with cirrhosis who develop venous clots.
-
PET/CT imaging to detect chemotherapy-related vascular harm in young cancer patients
A non-invasive PET/CT scan method using standard care imaging is being tested to identify which pediatric and young adult cancer patients are at higher risk of blood clots from chemotherapy.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large clinical trial will test whether taking rosuvastatin daily for a year helps prevent dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t already getting anticoagulants.
-
BCOR's role in blood clot risk and liver genetics
A Johns Hopkins-led study is exploring how a human gene, BCOR, may control liver-produced clotting factors to influence venous blood clots.
-
Personalized risk-prediction for hospital-acquired blood clots in adults
A real-time risk model helps doctors identify adults in the hospital who are at higher risk of developing blood clots so they can prevent them safely.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.