Improving decision-making and reducing compulsive drinking by targeting the brain's prefrontal cortex.
Targeting computation in prefrontal cortex to improve decision-making and reduce compulsive drinking in rodent models.
This study is looking at how problems with decision-making affect people with Alcohol Use Disorder and aims to find ways to improve these decisions by focusing on a specific part of the brain, which could help those dealing with alcohol dependence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10893468 on NIH RePORTER |
What this research studies
This research investigates how impairments in decision-making contribute to Alcohol Use Disorder (AUD) and aims to explore the neural mechanisms behind these behaviors. By focusing on the prefrontal cortex, the study seeks to understand how targeting this brain region can improve decision-making and reduce impulsivity in rodent models of AUD. The researchers will employ advanced techniques to manipulate and measure neural activity, providing insights that could lead to new treatment strategies for individuals struggling with alcohol dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder who exhibit impulsive decision-making behaviors.
Not a fit: Patients who do not have issues with alcohol use or decision-making may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve decision-making and reduce compulsive drinking in individuals with Alcohol Use Disorder.
How similar studies have performed: Previous studies have shown promising results in targeting the prefrontal cortex to influence addiction-related behaviors, suggesting that this approach may be effective.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lapish, Christopher Court — Indiana University Indianapolis
- Study coordinator: Lapish, Christopher Court
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.