Improving cryo-electron microscopy to study complex biological molecules
Advancing cryo-EM technology to address difficult biological questions
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11034109
This study is looking at how proteins, like the TRPV1 ion channel, change shape and work in response to different signals, which could help scientists create better drugs for patients by understanding these important biological processes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11034109 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing cryo-electron microscopy (cryo-EM) technology to better understand the structures and dynamics of challenging biological macromolecules, particularly proteins. By using the TRPV1 ion channel as a model, the research aims to explore how these proteins change shape and function in response to various signals. The approach involves capturing different conformational states of proteins, which can provide insights into their mechanisms of action and potential therapeutic targets. Patients may benefit from advancements in drug development that arise from a deeper understanding of these biological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to ion channel dysfunction or other protein-related diseases.
Not a fit: Patients with conditions unrelated to protein dynamics or those not affected by ion channel dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to protein dysfunction by providing insights into drug design and protein interactions.
How similar studies have performed: Previous research using cryo-EM has shown success in elucidating protein structures, indicating that this approach is promising and has the potential for significant breakthroughs.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, YIFAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: CHENG, YIFAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.