Improving cryo-electron microscopy for better imaging of biomolecules
Official title: Electron Energy Filtering System for Cryo-EM Imaging
Funded at Arizona State University-Tempe Campus · NIH-10847070 · Data updated 2026-11-12
This study is working on improving a special imaging technique called cryo-electron microscopy to help scientists get clearer pictures of tiny biological structures, which can lead to better understanding and new treatments for diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,999,997 |
| NIH project number | 1S10OD036204-01 |
| Project ID | NIH-10847070 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions that could be treated through advancements in drug design and biomolecular understanding.
✕Less likely to help
Patients with conditions unrelated to biomolecular structures or drug design may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing cryogenic electron microscopy (cryo-EM) capabilities at Arizona State University to improve the imaging of biomolecular structures. By upgrading the existing cryo-EM facility with a new energy filtering system, the project aims to reduce background noise and enhance image quality. This will allow researchers to obtain clearer images of complex biological specimens, which is crucial for understanding their functions and developing new medical applications. The upgraded system will also facilitate more efficient data collection, ultimately advancing research in structural biology and drug design.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding biomolecular structures, which may improve drug design and treatment strategies.
How similar studies have gone: Previous research in cryo-EM has shown significant success in enhancing imaging techniques, indicating that this approach has the potential for impactful results.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Chiu, Po-Lin — Arizona State University-Tempe Campus
- Study coordinator: Chiu, Po-Lin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.