Improving Cranial Bone Healing with Special Materials and Immune Cells
Microribbon scaffold-mediated Immunomodulation for Cranial Bone Repair
This work explores how new materials can guide the body's immune cells to better repair bone, especially in the skull.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11099850 on NIH RePORTER |
What this research studies
When bones heal, the body goes through several steps, including inflammation and forming new bone. This project looks at how immune cells, specifically macrophages, play a key role in this process. We are developing special 3D materials called microribbon scaffolds that can help these immune cells switch from causing inflammation to promoting healing. The goal is to create a better environment for bone regeneration, especially in difficult-to-heal areas like the skull.
Who could benefit from this research
Good fit: This research is relevant for patients who experience bone injuries or defects, especially those needing cranial bone repair.
Not a fit: Patients without bone injuries or those with conditions unrelated to bone healing would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could lead to faster and more complete healing of bone defects, particularly in the skull, by optimizing the body's natural repair mechanisms.
How similar studies have performed: While previous studies have shown that biomaterials can influence immune responses in soft tissues, this work is novel in applying these principles to bone healing and using advanced 3D scaffold designs.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Yang, Fan — Stanford University
- Study coordinator: Yang, Fan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.