Improving corneal collagen crosslinking therapy using advanced imaging techniques
Official title: Noncontact in vivo guidance of corneal collagen crosslinking therapy with optical coherence tomography and acoustic micro-tapping elastography
Funded at University of Washington · NIH-11095998 · Data updated 2026-11-12
This study is testing a new, gentle way to check the strength and shape of the cornea in people with keratoconus, which could help doctors improve treatments and outcomes for managing this eye condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $608,808 |
| NIH project number | 5R01EY035647-02 |
| Project ID | NIH-11095998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with keratoconus who are considering or undergoing corneal collagen crosslinking therapy.
✕Less likely to help
Patients with other forms of corneal disease or those who do not have keratoconus may not benefit from this research.
What this research studies
This research focuses on developing a non-invasive tool that uses Optical Coherence Tomography (OCT) and acoustic micro-tapping elastography to assess the mechanical properties of the cornea in patients with keratoconus. By accurately mapping the corneal geometry and its elastic properties, the study aims to enhance the effectiveness of corneal collagen crosslinking therapy, which is designed to slow the progression of corneal ectasia. Patients will benefit from improved diagnostics and treatment planning, potentially leading to better outcomes in managing their condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with keratoconus, improving their vision and quality of life.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for corneal assessments, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Pelivanov, Ivan — University of Washington
- Study coordinator: Pelivanov, Ivan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.