NIH-funded research R01 grant

Improving COPD self-care programs

Official title: Optimizing Effectiveness and Implementation of COPD Self-Management Treatment

Funded at Rush University Medical Center · NIH-11301806 · Data updated 2026-11-12

This project tries different parts of a COPD self-care program—education, physical activity, and inhaler training—to see which combinations help adults with COPD who had a flare-up in the past year.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionRush University Medical Center
NIH-funded
Lab location1 site (Chicago, United States)
Project startMarch 15, 2025
Project endNovember 30, 2029
Funding year2026
Award (this year)$687,320
NIH project number5R01HL173120-02
Project IDNIH-11301806 on NIH RePORTER

Who could benefit from this research

Could help

Adults (21+) with a physician-diagnosed COPD who had an exacerbation in the past year and who can participate in program activities and follow-up are ideal candidates.

Less likely to help

People without COPD, those who have not had a recent exacerbation, or those unable to take part in program activities or follow-up (for example due to severe illness or inability to travel) are unlikely to benefit.

What this research studies

You would be part of a program that tests different combinations of self-management education, guided physical activity, and inhaler training. The team will enroll 448 adults with a doctor's diagnosis of COPD who experienced an exacerbation in the past year. The trial uses a factorial design over 12 months to compare which components or combinations reduce respiratory-related hospitalizations and to study how practical and affordable each option is to deliver. The goal is to create a simpler, lower-cost self-care program that clinics can realistically offer.

Why it matters

Potential benefit: If successful, this could lower COPD-related hospitalizations and make effective self-care programs easier and cheaper for clinics to offer.

How similar studies have gone: Prior COPD self-management programs have reduced hospitalizations and improved quality of life, but using a systematic optimization approach to find the best combination of components is relatively new.

Where this research is happening

  • Rush University Medical Center
    Chicago, United States
    Active

Researchers

  • Principal investigator: Mathew, Amanda R — Rush University Medical Center
  • Study coordinator: Mathew, Amanda R

Related research

Other NIH-funded projects on the same topics.

  • Comprehensive home-based coaching to help COPD patients manage their care

    A doctor-managed program helps adults with COPD manage daily treatments, recognize early signs of flare-ups, and access home-based rehab with support from community health workers.

    NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11292426

  • Improving self-management for people with COPD

    This study is looking to make self-management programs better for people with COPD by figuring out what works best, and it will involve 448 participants who will learn about managing their condition, staying active, and using their inhalers correctly, all with the goal of helping them feel better and stay out of the ho

    NIH research Rush University Medical Center · Chicago, United States · NIH-11047967

  • Home-based coaching for managing COPD

    This study is testing a friendly coaching program at home to help people with COPD better manage their health by addressing their unique challenges and providing personalized support from community health workers.

    NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11019788

  • Omalizumab for COPD patients with allergen sensitization and exposure

    A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11624859

  • Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes

    A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.

    NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11594416

  • Clinical CT Imaging to identify and subtype pulmonary hypertension in COPD

    A new CT imaging approach aims to help doctors detect and classify pulmonary hypertension in people with COPD.

    NIH research University of California Los Angeles · Los Angeles, United States · NIH-11583955

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.