Improving continuous monitoring of large proteins in chronic diseases
Official title: Aptamer tagging with redox quenchers: a critical breakthrough in the sensitivity of continuous electrochemical protein monitoring
Funded at University of Cincinnati · NIH-11029960 · Data updated 2026-11-12
This study is working on new sensors that can keep an eye on important proteins in your body to help manage chronic diseases better, giving you and your doctors real-time updates about your health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $170,678 |
| NIH project number | 1R21EB036615-01 |
| Project ID | NIH-11029960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic diseases that require continuous monitoring of large proteins, such as cardiac conditions or inflammatory disorders.
✕Less likely to help
Patients with acute conditions or those not requiring continuous monitoring of large proteins may not benefit from this research.
What this research studies
This research focuses on developing advanced sensors that can continuously monitor large proteins and peptides in the body, which is crucial for managing chronic diseases. By using innovative aptamer technology combined with redox quenchers, the researchers aim to enhance the sensitivity of these sensors, allowing for real-time tracking of important biological markers. Patients will benefit from more accurate and timely information about their health, potentially leading to better management of their conditions. The study involves in-vivo testing to ensure the sensors work effectively in a living organism.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring and management of chronic diseases through improved detection of large proteins.
How similar studies have gone: While continuous monitoring of small molecules has seen success, this approach for large proteins is novel and has not been previously demonstrated.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Heikenfeld, Jason — University of Cincinnati
- Study coordinator: Heikenfeld, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.