Improving colorectal cancer treatment by targeting specific proteins
Official title: Targeting ß-TrCP regulators to improve CRC response to chemotherapy
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11049159 · Data updated 2026-11-12
This study is looking at how certain proteins affect the growth of colorectal cancer and how well chemotherapy works, with the goal of finding new ways to make treatment more effective for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | March 5, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $673,747 |
| NIH project number | 5R01CA288849-02 |
| Project ID | NIH-11049159 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer who are undergoing or are eligible for chemotherapy.
✕Less likely to help
Patients with non-colorectal cancers or those who are not receiving chemotherapy may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of chemotherapy for colorectal cancer (CRC) by investigating key proteins that regulate tumor growth and response to treatment. The study aims to understand how proteins like IGF2BP1 and PARP11 influence cancer cell survival and their interaction with the immune system. By manipulating these proteins in laboratory settings, researchers hope to identify new strategies that can improve the efficacy of standard chemotherapy regimens for CRC patients. The approach includes both genetic modifications and analysis of tumor microenvironments to assess treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to more effective chemotherapy options for colorectal cancer patients, potentially improving survival rates and quality of life.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this novel approach.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Spiegelman, Vladimir S. — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Spiegelman, Vladimir S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.