Improving colorectal cancer risk prediction for diverse racial and ethnic groups
Advancing equity in colorectal cancer genetic risk prediction through expansion of racial/ethnic minority representation
This study is working to make colorectal cancer risk predictions better for everyone, no matter their background, by creating a new tool that uses genetic information from diverse groups, and patients will help test these new methods to improve screening and prevention.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10873165 on NIH RePORTER |
What this research studies
This research focuses on enhancing the accuracy of colorectal cancer (CRC) risk predictions by developing polygenic risk scores (PRS) that are inclusive of various racial and ethnic backgrounds. The project aims to address the current limitations of PRS, which predominantly benefit individuals of European ancestry, by creating a more equitable risk assessment tool. By incorporating diverse genetic data, the research seeks to improve screening strategies and communication tools for CRC prevention. Patients will be involved in the validation of these new risk scores and screening approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from various racial and ethnic backgrounds, particularly those who are at risk for colorectal cancer.
Not a fit: Patients who are not at risk for colorectal cancer or those who do not belong to underrepresented racial or ethnic groups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and equitable colorectal cancer risk assessments for patients from diverse backgrounds, ultimately improving prevention and early detection.
How similar studies have performed: Other research has shown promise in developing inclusive genetic risk assessment tools, but this approach aims to address a significant gap in the current methodologies.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Peters, Ulrike — Fred Hutchinson Cancer Center
- Study coordinator: Peters, Ulrike
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.