Improving colorectal cancer prevention through personalized screening and genetic data.
Official title: Personalized Colorectal Cancer Prevention: Integrating Individual Screening and Follow Up Information with Genetic Data
Funded at Durham VA Medical Center · NIH-10925426 · Data updated 2026-11-12
This study is looking to improve how we prevent colorectal cancer by combining personal screening history with genetic information, so we can better identify who needs more frequent check-ups and who can wait, making sure everyone gets the right care at the right time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Durham VA Medical Center NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| NIH project number | 1IK2BX006452-01A1 |
| Project ID | NIH-10925426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of colorectal cancer or other risk factors that may warrant earlier or more frequent screening.
✕Less likely to help
Patients who are at low risk for colorectal cancer and do not have any relevant family history or genetic predispositions may not benefit from this research.
What this research studies
This research aims to enhance colorectal cancer (CRC) prevention by integrating individual screening and follow-up information with genetic data. It focuses on developing more precise risk stratification methods that consider both clinical and genetic factors, allowing for tailored screening approaches. By identifying individuals at higher risk for CRC, the study seeks to optimize the use of colonoscopy resources, ensuring timely and appropriate screening while minimizing unnecessary procedures for those at lower risk. The research will utilize extensive VA resources, including clinical repositories and genomic biobanks, to refine current risk-assessment algorithms.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized colorectal cancer prevention strategies, ultimately reducing the incidence of the disease.
How similar studies have gone: Previous research has shown promise in using genetic data to improve cancer screening strategies, indicating that this approach could be effective.
Where this research is happening
-
Durham VA Medical Center
Durham, United States Active
Researchers
- Principal investigator: Sullivan, Brian Andrew — Durham VA Medical Center
- Study coordinator: Sullivan, Brian Andrew
Related research
Other NIH-funded projects on the same topics.
-
Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
-
Colorectal cancer prognosis through a broad, collaborative study
A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.
-
Ceramides and how they affect metabolism and colorectal cancer in adults
A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.
-
Automated point-of-care DNA methylation test for colorectal cancer in LMICs
A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.
-
Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation
A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.
-
Comparative modeling to guide colorectal cancer screening and care
A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.