Improving cognitive function to delay dementia onset
Official title: ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia
Funded at University of Alabama at Birmingham · NIH-11145538 · Data updated 2026-11-12
This study is looking at how different computer-based brain exercises can help older adults with mild cognitive impairment think better and possibly slow down the onset of dementia, so if you're interested in improving your brain health, this might be for you!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $4,555,241 |
| NIH project number | 7R01AG075014-03 |
| Project ID | NIH-11145538 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have been diagnosed with mild cognitive impairment (MCI).
✕Less likely to help
Patients who do not have mild cognitive impairment or who are already diagnosed with advanced dementia may not benefit from this research.
What this research studies
This research investigates how different types of computerized cognitive training can help improve everyday functioning and potentially delay the onset of dementia in older adults with mild cognitive impairment (MCI). Participants will engage in various cognitive training exercises, and the study aims to identify which specific exercises are most effective. By using an adaptive trial design, the research will adjust based on participant responses to find the best approach for enhancing cognitive health. The goal is to provide clearer recommendations for preventing Alzheimer's disease and related dementias.
Why it matters
Potential benefit: If successful, this research could lead to effective cognitive training programs that help delay the onset of dementia in at-risk individuals.
How similar studies have gone: Previous studies have shown promising results with cognitive training in reducing the risk of dementia, indicating that this approach has potential for success.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Edwards, Jerri — University of Alabama at Birmingham
- Study coordinator: Edwards, Jerri
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.