Improving cognitive function to delay dementia onset

ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia

['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11145538

This study is looking at how different computer-based brain exercises can help older adults with mild cognitive impairment think better and possibly slow down the onset of dementia, so if you're interested in improving your brain health, this might be for you!

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded)
Locations1 site (BIRMINGHAM, UNITED STATES)
Trial IDNIH-11145538 on ClinicalTrials.gov

What this research studies

This research investigates how different types of computerized cognitive training can help improve everyday functioning and potentially delay the onset of dementia in older adults with mild cognitive impairment (MCI). Participants will engage in various cognitive training exercises, and the study aims to identify which specific exercises are most effective. By using an adaptive trial design, the research will adjust based on participant responses to find the best approach for enhancing cognitive health. The goal is to provide clearer recommendations for preventing Alzheimer's disease and related dementias.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults who have been diagnosed with mild cognitive impairment (MCI).

Not a fit: Patients who do not have mild cognitive impairment or who are already diagnosed with advanced dementia may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to effective cognitive training programs that help delay the onset of dementia in at-risk individuals.

How similar studies have performed: Previous studies have shown promising results with cognitive training in reducing the risk of dementia, indicating that this approach has potential for success.

Where this research is happening

BIRMINGHAM, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Alzheimer disease dementia, Alzheimer syndrome

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.