Improving cognitive function in individuals with Down syndrome as they age
Targeting protein synthesis dysregulation in Down syndrome-associated cognitive impairment with aging
This study is looking at how aging affects memory and thinking skills in people with Down syndrome, especially as they may face a higher risk of Alzheimer's, and it’s testing a possible treatment that could help improve brain function and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-11011741 on NIH RePORTER |
What this research studies
This research investigates the cognitive impairments associated with Down syndrome, particularly as individuals age and become more susceptible to Alzheimer's disease. The study aims to understand the cellular mechanisms behind these cognitive deficits and explores a potential treatment that enhances protein synthesis in the brain. By targeting specific proteins involved in synaptic function, the research seeks to improve memory and cognitive abilities in mouse models that mimic Down syndrome. If successful, this could lead to new therapies for individuals with Down syndrome experiencing cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those experiencing cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who do not exhibit cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive function and quality of life for individuals with Down syndrome as they age.
How similar studies have performed: Previous research has shown promising results in targeting protein synthesis to improve cognitive function in other neurodegenerative conditions, suggesting potential success for this approach in Down syndrome.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Ma, Tao — Wake Forest University Health Sciences
- Study coordinator: Ma, Tao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.