Improving cognitive function in individuals with Down syndrome as they age
Targeting protein synthesis dysregulation in Down syndrome-associated cognitive impairments with aging
This study is looking at how a specific protein might help improve thinking and memory in older people with Down syndrome by making changes in the brain, and it aims to find new ways to support their cognitive health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10992329 on NIH RePORTER |
What this research studies
This research investigates how changes in protein synthesis can affect cognitive impairments associated with aging in individuals with Down syndrome. By focusing on a specific protein called eEF2K, the study aims to understand how its regulation can improve brain function and reduce cognitive decline. Using a novel mouse model, researchers will explore the effects of manipulating this protein on synaptic health and cognitive abilities, providing insights that could translate into therapeutic strategies for patients. The approach combines molecular biology techniques with behavioral assessments to evaluate cognitive outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome who are experiencing cognitive decline or related impairments as they age.
Not a fit: Patients without Down syndrome or those not experiencing cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive function and quality of life for individuals with Down syndrome as they age.
How similar studies have performed: Previous research has shown promising results in targeting protein synthesis to improve cognitive function in other conditions, suggesting potential for success in this novel approach.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Ma, Tao — Wake Forest University Health Sciences
- Study coordinator: Ma, Tao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.