Improving cognitive function after seizures using EP2 antagonists
Optimization of EP2 Antagonists for Post-Seizure Cognitive Deficits
This study is looking at how to help people with epilepsy who have trouble thinking clearly after seizures by testing new medicines that might improve their brain function and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10877946 on NIH RePORTER |
What this research studies
This research focuses on addressing cognitive deficits that often accompany epilepsy, a common neurological disorder. The team is investigating the role of EP2 receptors in inflammation and cognitive decline following seizures. By synthesizing and testing new compounds that block these receptors, the researchers aim to identify effective treatments that could improve cognitive function and overall quality of life for patients with epilepsy. The study involves rigorous testing of these compounds to ensure they are safe and effective before moving to clinical trials.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epilepsy who experience cognitive deficits.
Not a fit: Patients without epilepsy or those whose cognitive deficits are unrelated to seizure activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with epilepsy.
How similar studies have performed: Previous research has shown promise in targeting EP2 receptors for cognitive improvement in animal models, indicating potential for success in this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Ganesh, Thota — Emory University
- Study coordinator: Ganesh, Thota
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.