Improving cochlear implant outcomes by monitoring and reducing oxidative stress
Real-Time Monitoring and Scavenging of Reactive Oxygen Species (ROS) toEnhance Cochlear Implantation Outcomes
This study is looking to make cochlear implants work better for people with hearing loss by creating special electrodes that can track and reduce harmful molecules during and after surgery, helping to improve hearing results for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11116647 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of cochlear implants for individuals with hearing loss by addressing the challenges posed by oxidative stress during and after surgery. The team aims to develop advanced cochlear implant electrodes that can monitor reactive oxygen species (ROS) levels in real-time and actively scavenge these harmful molecules. By understanding and mitigating the inflammatory response that occurs during implantation, the goal is to improve post-operative hearing outcomes for patients. This innovative approach combines real-time sensing with therapeutic action to potentially enhance the overall success of cochlear implantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are deaf or have significant hearing loss and are considering cochlear implantation.
Not a fit: Patients who do not require cochlear implants or have contraindications for surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved hearing restoration outcomes for patients receiving cochlear implants.
How similar studies have performed: While the approach of real-time monitoring and scavenging of oxidative stress in cochlear implantation is innovative, similar strategies have shown promise in other areas of neuroprotection and inflammation management.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Zeng, Xiangqun — University of Missouri-Columbia
- Study coordinator: Zeng, Xiangqun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.